miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer
Background. Gastric cancer (GC) is an important malignant disease around the world. Abnormalities of microRNAs (miRNAs) have been implicated in carcinogenesis of various cancers. In the present study, we examined miR-21 expression in human gastric cancer with lymph node metastasis and attempted to u...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/640168 |
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| _version_ | 1849396456008450048 |
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| author | Yuejuan Xu Jue Sun Jianhua Xu Qi Li Yuewu Guo Qiang Zhang |
| author_facet | Yuejuan Xu Jue Sun Jianhua Xu Qi Li Yuewu Guo Qiang Zhang |
| author_sort | Yuejuan Xu |
| collection | DOAJ |
| description | Background. Gastric cancer (GC) is an important malignant disease around the world. Abnormalities of microRNAs (miRNAs) have been implicated in carcinogenesis of various cancers. In the present study, we examined miR-21 expression in human gastric cancer with lymph node metastasis and attempted to uncover its relationship with clinicopathologic data, especially with lymph node metastasis. Materials and Methods. The expression levels of miR-21 in the tumor specimens of GC patients were quantified by RT-PCR. The correlation between miR-21 level and multiple clinicopathological factors was then examined by Mann-Whitney test, Kaplan-Meier survival analysis, and operating characteristic (ROC) analysis. Results. The expression level of miR-21 was higher in GC patients with lymph node metastasis than in those without lymph node metastasis (P<0.05). Expression level of miR-21 was significantly correlated with histologic type, T stage, lymph node metastasis and pTNM stage. The overall survival rates in GC patients with low upregulated miR-21 expression were significantly higher than those with high upregulated miR-21 (P<0.05). Conclusion. A close association is implicated between the elevated miR-21and lymph node metastasis, which could potentially be exploited as a practical biomarker for lymph node metastasis in patients with GC. |
| format | Article |
| id | doaj-art-b2db907b8b9f41c0b72d84a24fc828e9 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b2db907b8b9f41c0b72d84a24fc828e92025-08-20T03:39:19ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/640168640168miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric CancerYuejuan Xu0Jue Sun1Jianhua Xu2Qi Li3Yuewu Guo4Qiang Zhang5Department of Oncology, The Second Hospital of Nanjing, South East University, Nanjing 210003, ChinaDepartment of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, ChinaDepartment of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, ChinaDepartment of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, ChinaDepartment of Oncology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, ChinaDepartment of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, ChinaBackground. Gastric cancer (GC) is an important malignant disease around the world. Abnormalities of microRNAs (miRNAs) have been implicated in carcinogenesis of various cancers. In the present study, we examined miR-21 expression in human gastric cancer with lymph node metastasis and attempted to uncover its relationship with clinicopathologic data, especially with lymph node metastasis. Materials and Methods. The expression levels of miR-21 in the tumor specimens of GC patients were quantified by RT-PCR. The correlation between miR-21 level and multiple clinicopathological factors was then examined by Mann-Whitney test, Kaplan-Meier survival analysis, and operating characteristic (ROC) analysis. Results. The expression level of miR-21 was higher in GC patients with lymph node metastasis than in those without lymph node metastasis (P<0.05). Expression level of miR-21 was significantly correlated with histologic type, T stage, lymph node metastasis and pTNM stage. The overall survival rates in GC patients with low upregulated miR-21 expression were significantly higher than those with high upregulated miR-21 (P<0.05). Conclusion. A close association is implicated between the elevated miR-21and lymph node metastasis, which could potentially be exploited as a practical biomarker for lymph node metastasis in patients with GC.http://dx.doi.org/10.1155/2012/640168 |
| spellingShingle | Yuejuan Xu Jue Sun Jianhua Xu Qi Li Yuewu Guo Qiang Zhang miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer Gastroenterology Research and Practice |
| title | miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer |
| title_full | miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer |
| title_fullStr | miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer |
| title_full_unstemmed | miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer |
| title_short | miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer |
| title_sort | mir 21 is a promising novel biomarker for lymph node metastasis in patients with gastric cancer |
| url | http://dx.doi.org/10.1155/2012/640168 |
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