Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy
This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization analysis was conducted based on a national anonymized databa...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2024-0017 |
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| author | Jazbar Janja Locatelli Igor Kos Mitja |
| author_facet | Jazbar Janja Locatelli Igor Kos Mitja |
| author_sort | Jazbar Janja |
| collection | DOAJ |
| description | This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization analysis was conducted based on a national anonymized database of dispensed prescriptions from 2009 to 2019. The study employed the sedative load model and the anticholinergic cognitive burden scale to assess the sedative and anti cholinergic burden, respectively. The findings indicate that in 2019, 45.6 % and 40.8 % of older adults (≥ 65 years) used sedative and anticholinergic medications, respectively. A high sedative load and a clinically significant anticholinergic burden were observed in a considerable proportion of older adults (13.2 % and 11.2 %, respectively, in 2019). The age-standardized prevalence of sedative load and anti-cholinergic burden significantly decreased over the 10-year study period by 5.6 % and 1.7 %, respectively (absolute difference), while the prevalence of clinically significant anticholinergic burden remained stable. Notably, the age groups 85–89 years and above 90 years had an increase in the proportion of individuals with a clinically significant anticholinergic burden over the years. These results emphasize the need for targeted interventions, particularly in the oldest age groups, to promote safe and effective medication use among older adults. |
| format | Article |
| id | doaj-art-b2d379355a6e47f18a043236be27522f |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-b2d379355a6e47f18a043236be27522f2025-02-02T23:21:02ZengSciendoActa Pharmaceutica1846-95582024-06-0174232934110.2478/acph-2024-0017Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapyJazbar Janja0Locatelli Igor1Kos Mitja21University of Ljubljana, Faculty of Pharmacy1000Ljubljana, Slovenia1University of Ljubljana, Faculty of Pharmacy1000Ljubljana, Slovenia1University of Ljubljana, Faculty of Pharmacy1000Ljubljana, SloveniaThis study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization analysis was conducted based on a national anonymized database of dispensed prescriptions from 2009 to 2019. The study employed the sedative load model and the anticholinergic cognitive burden scale to assess the sedative and anti cholinergic burden, respectively. The findings indicate that in 2019, 45.6 % and 40.8 % of older adults (≥ 65 years) used sedative and anticholinergic medications, respectively. A high sedative load and a clinically significant anticholinergic burden were observed in a considerable proportion of older adults (13.2 % and 11.2 %, respectively, in 2019). The age-standardized prevalence of sedative load and anti-cholinergic burden significantly decreased over the 10-year study period by 5.6 % and 1.7 %, respectively (absolute difference), while the prevalence of clinically significant anticholinergic burden remained stable. Notably, the age groups 85–89 years and above 90 years had an increase in the proportion of individuals with a clinically significant anticholinergic burden over the years. These results emphasize the need for targeted interventions, particularly in the oldest age groups, to promote safe and effective medication use among older adults.https://doi.org/10.2478/acph-2024-0017sedative loadanticholinergic burdenolder adultspharmaco-therapy optimizationdrug utilization studypharmacoepidemiology study |
| spellingShingle | Jazbar Janja Locatelli Igor Kos Mitja Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy Acta Pharmaceutica sedative load anticholinergic burden older adults pharmaco-therapy optimization drug utilization study pharmacoepidemiology study |
| title | Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy |
| title_full | Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy |
| title_fullStr | Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy |
| title_full_unstemmed | Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy |
| title_short | Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy |
| title_sort | sedative load and anticholinergic burden among older adults in slovenia over a decade potential for optimization of pharmacotherapy |
| topic | sedative load anticholinergic burden older adults pharmaco-therapy optimization drug utilization study pharmacoepidemiology study |
| url | https://doi.org/10.2478/acph-2024-0017 |
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