Isoalantolactone induces the apoptosis of oxaliplatin-resistant human colorectal cancer cells mediated by ROS generation and activation of JNK and p38 MAPK

Isoalantolactone induces the apoptosis of oxaliplatin-resistant human colorectal cancer cells mediated by ROS generation and activation of JNK and p38 MAPK

Abstract Treating colorectal cancer (CRC) poses challenges due to the lack of specific molecular targets. Although oxaliplatin (Ox) is commonly used to treat CRC, resistance frequently develops, necessitating the discovery of new therapeutics. This study explored the anticancer effects of Isoalantol...

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Bibliographic Details
Main Authors: Seung-On Lee, Sang Hoon Joo, Na Yeong Lee, Seung-Sik Cho, Goo Yoon, Ki-Taek Kim, Yung Hyun Choi, Jin Woo Park, Joon-Seok Choi, Jung-Hyun Shim
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Isoalantolactone
Apoptosis
Colorectal cancer
Oxaliplatin
Reactive oxygen species
JNK/p38 MAPK
Online Access:https://doi.org/10.1038/s41598-025-98499-7
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https://doi.org/10.1038/s41598-025-98499-7

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