Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi Arabia
Introduction. The risk of developing transfusion-related complications, especially alloimmunization, is an ongoing concern for transfusion-dependent patients. It is important to determine the rate of alloimmunization and autoimmunization in Al-Ahsa Region, Saudi Arabia, where sickle cell disease (SC...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Anemia |
| Online Access: | http://dx.doi.org/10.1155/2023/3239960 |
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| author | Fahd A. Kuriri Abdulrahman Ahmed Fehaid Alanazi Fahad Alhumud Mohammed Ageeli Hakami Osama Atiatalla Babiker Ahmed |
| author_facet | Fahd A. Kuriri Abdulrahman Ahmed Fehaid Alanazi Fahad Alhumud Mohammed Ageeli Hakami Osama Atiatalla Babiker Ahmed |
| author_sort | Fahd A. Kuriri |
| collection | DOAJ |
| description | Introduction. The risk of developing transfusion-related complications, especially alloimmunization, is an ongoing concern for transfusion-dependent patients. It is important to determine the rate of alloimmunization and autoimmunization in Al-Ahsa Region, Saudi Arabia, where sickle cell disease (SCD) and thalassemia incidence rates are the highest in Saudi Arabia. Methods. A cross-sectional study was conducted to review the transfusion history of patients with SCD and thalassemia at the King Fahad Hospital (KFH) in Al-Ahsa, Saudi Arabia. 364 transfusion-dependent patients were included in this study. Results. Alloimmunization rates in patients with SCD and thalassemia were 16.7% and 11.97%, respectively, while autoimmunization rates in patients with SCD and thalassemia were 5.3% and 0.7%, respectively. The most frequent alloantibodies among the study participants were against Kell, Rh blood group systems. Conclusion. Blood transfusion-related alloimmunization and autoimmunization compromise the proper management of chronically transfused patients. Ideally, extended matched phenotyping should be implemented to prevent alloimmunization and reduce the risk of developing blood transfusion-related alloantibodies. |
| format | Article |
| id | doaj-art-b2a5478991b4464a9ce9fb62344ff1e3 |
| institution | Kabale University |
| issn | 2090-1275 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anemia |
| spelling | doaj-art-b2a5478991b4464a9ce9fb62344ff1e32025-02-03T06:45:09ZengWileyAnemia2090-12752023-01-01202310.1155/2023/3239960Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi ArabiaFahd A. Kuriri0Abdulrahman Ahmed1Fehaid Alanazi2Fahad Alhumud3Mohammed Ageeli Hakami4Osama Atiatalla Babiker Ahmed5Department of Clinical Laboratory SciencesAl-Ahsa Health ClusterDepartment of Clinical Laboratory SciencesAl-Ahsa Health ClusterDepartment of Clinical Laboratory SciencesDepartment of Clinical Laboratory SciencesIntroduction. The risk of developing transfusion-related complications, especially alloimmunization, is an ongoing concern for transfusion-dependent patients. It is important to determine the rate of alloimmunization and autoimmunization in Al-Ahsa Region, Saudi Arabia, where sickle cell disease (SCD) and thalassemia incidence rates are the highest in Saudi Arabia. Methods. A cross-sectional study was conducted to review the transfusion history of patients with SCD and thalassemia at the King Fahad Hospital (KFH) in Al-Ahsa, Saudi Arabia. 364 transfusion-dependent patients were included in this study. Results. Alloimmunization rates in patients with SCD and thalassemia were 16.7% and 11.97%, respectively, while autoimmunization rates in patients with SCD and thalassemia were 5.3% and 0.7%, respectively. The most frequent alloantibodies among the study participants were against Kell, Rh blood group systems. Conclusion. Blood transfusion-related alloimmunization and autoimmunization compromise the proper management of chronically transfused patients. Ideally, extended matched phenotyping should be implemented to prevent alloimmunization and reduce the risk of developing blood transfusion-related alloantibodies.http://dx.doi.org/10.1155/2023/3239960 |
| spellingShingle | Fahd A. Kuriri Abdulrahman Ahmed Fehaid Alanazi Fahad Alhumud Mohammed Ageeli Hakami Osama Atiatalla Babiker Ahmed Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi Arabia Anemia |
| title | Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi Arabia |
| title_full | Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi Arabia |
| title_fullStr | Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi Arabia |
| title_full_unstemmed | Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi Arabia |
| title_short | Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi Arabia |
| title_sort | red blood cell alloimmunization and autoimmunization in blood transfusion dependent sickle cell disease and β thalassemia patients in al ahsa region saudi arabia |
| url | http://dx.doi.org/10.1155/2023/3239960 |
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