Microvascular dysfunction in a murine model of Alzheimer’s disease using intravital microscopy

Microvascular dysfunction in a murine model of Alzheimer’s disease using intravital microscopy

Alzheimer’s disease (AD) is a complex neurocognitive disorder. Early theories of AD sought to identify a single unifying explanation underlying AD pathogenesis; however, evolving evidence suggests it is a multifactorial, systemic disease, involving multiple systems. Of note, vascular dysfunction, en...

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Bibliographic Details
Main Authors: Danielle Sidsworth, Noah Tregobov, Colin Jamieson, Jennifer Reutens-Hernandez, Joshua Yoon, Geoffrey W. Payne, Stephanie L. Sellers
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
microvascular dysfunction
murine model
neurodegeneration
vasoreactivity
intravital microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1482250/full
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