Sonic hedgehog medulloblastomas are dependent on Netrin-1 for survival

Sonic hedgehog medulloblastomas are dependent on Netrin-1 for survival

Abstract Netrin-1 signaling is an essential prototypical neuronal guidance mechanism during embryonic development that also regulates tumor cell survival in a variety of adult cancer entities. In line with these data, a monoclonal netrin-1 blocking antibody (anti-netrin-1 mAb/NP137) has been preclin...

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Main Authors: Julie Talbot, Joanna Fombonne, Jacob Torrejon, Benjamin R. Babcock, Leon F. McSwain, Nicolas Rama, Ludovica Lospinoso Severini, Emma Bonerandi, Veronique Marsaud, Flavia Bernardi, Tarek Gharsalli, Catherine Guix, Benjamin Ducarouge, Verena Neururer, Irene Basili, Audrey L. Mercier, Hua Yu, Antoine Forget, Emilie Indersie, Sophie Leboucher, Judith Souphron, Konstantin Okonechnikov, Wanchen Wang, Daisuke Kawauchi, Brandon J. Wainwright, Didier Frappaz, Pascale Varlet, Christelle Dufour, Kevin Beccaria, Thomas Blauwblomme, Loredana Martignetti, Lucia Di Marcotullio, Stéphanie Puget, François Doz, Franck Bourdeaut, Julien Masliah-Planchon, Timothy R. Gershon, Patrick Mehlen, Olivier Ayrault
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59612-6
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https://doi.org/10.1038/s41467-025-59612-6

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