CAR-T cells targeting CCR9 and CD1a for the treatment of T cell acute lymphoblastic leukemia

CAR-T cells targeting CCR9 and CD1a for the treatment of T cell acute lymphoblastic leukemia

Abstract T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy characterized by high rates of induction failure and relapse, and effective targeted immunotherapies are lacking. Despite promising clinical progress with genome-edited CD7-directed CAR-T cells, which present significan...

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Main Authors: Néstor Tirado, Klaudyna Fidyt, María José Mansilla, Alba Garcia-Perez, Alba Martínez-Moreno, Meritxell Vinyoles, Juan Alcain, Marina García-Peydró, Heleia Roca-Ho, Narcis Fernandez-Fuentes, Mercedes Guerrero-Murillo, Aïda Falgàs, Talia Velasco-Hernandez, Clara Bueno, Patrizio Panelli, Vladimir Mulens-Arias, Apostol Apostolov, Pablo Engel, Europa Azucena González, Binje Vick, Irmela Jeremias, Aurélie Caye-Eude, André Baruchel, Hélène Cavé, Eulàlia Genescà, Jordi Ribera, Marina Díaz-Beyá, María Victoria Martínez-Sánchez, José Luis Fuster, Adela Escudero López, Jordi Minguillón, Antonio Pérez-Martínez, Manuel Ramírez-Orellana, Montserrat Torrebadell, Víctor M Díaz, María L Toribio, Diego Sánchez-Martínez, Pablo Menéndez
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Hematology & Oncology
Online Access:https://doi.org/10.1186/s13045-025-01715-0
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https://doi.org/10.1186/s13045-025-01715-0

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