Empagliflozin Plays Vasoprotective Role in Spontaneously Hypertensive Rats via Activation of the SIRT1/AMPK Pathway

Empagliflozin Plays Vasoprotective Role in Spontaneously Hypertensive Rats via Activation of the SIRT1/AMPK Pathway

Empagliflozin (EMPA), a sodium-glucose co-transporter 2 (SGLT2) inhibitor, prevents endothelial dysfunction, but its effects on vascular tone in hypertension remain unclear. This study investigated whether EMPA modulates vasomotor tone via sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) pa...

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Bibliographic Details
Main Authors: Monika Kloza, Anna Krzyżewska, Hanna Kozłowska, Sandra Budziak, Marta Baranowska-Kuczko
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
empagliflozin
SGLT2 inhibitors
sirtuin 1
AMPK
spontaneously hypertensive rat
vasoprotection
Online Access:https://www.mdpi.com/2073-4409/14/7/507
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https://www.mdpi.com/2073-4409/14/7/507

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