WWP1 targeting PTEN for polyubiquitination to promote bone metastasis of luminal breast cancer

WWP1 targeting PTEN for polyubiquitination to promote bone metastasis of luminal breast cancer

Abstract Luminal breast cancer exhibits a high incidence of bone recurrence when metastasizing to distant organs. The mechanisms underlying the organotropism of luminal breast cancer cells remain unclear. In this study, we aimed to determine the role of WWP1 (WW domain-containing E3 ubiquitin protei...

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Bibliographic Details
Main Authors: Hao Jiang, Zhenxi Li, Wei Xu, Jianru Xiao
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
WWP1
PTEN
Luminal breast cancer
Bone metastasis
Ubiquitination
Online Access:https://doi.org/10.1038/s41598-024-81541-5
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