Structural comparison of human and Plasmodium proteasome β5 subunits: informing selective inhibitor design for anti-malaria agents

Structural comparison of human and Plasmodium proteasome β5 subunits: informing selective inhibitor design for anti-malaria agents

Abstract Background The Plasmodium proteasome emerges as a promising target for anti-malarial drug development due to its potential activity against multiple life cycle stages. Methods In this investigation, a comparative analysis was conducted on the structural features of the β5 subunit in the 20S...

Full description

Saved in:
Bibliographic Details
Main Authors: Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Wanjoo Chun
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Malaria Journal
Subjects:
Plasmodium
Proteasome β5 subunits
Malaria
Molecular dynamic simulation
Proteasome inhibition
Online Access:https://doi.org/10.1186/s12936-025-05259-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items