Structural comparison of human and Plasmodium proteasome β5 subunits: informing selective inhibitor design for anti-malaria agents

Abstract Background The Plasmodium proteasome emerges as a promising target for anti-malarial drug development due to its potential activity against multiple life cycle stages. Methods In this investigation, a comparative analysis was conducted on the structural features of the β5 subunit in the 20S...

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Bibliographic Details
Main Authors: Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Wanjoo Chun
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Malaria Journal
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Online Access:https://doi.org/10.1186/s12936-025-05259-z
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