Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements
In recent times, individuals are focusing more on natural substances, primarily due to their safety and non-toxicity. Also, there is an increasing demand by industries for the phytoconstituents that might be incorporated in pharmaceuticals, cosmetics, dietary products and nutraceuticals. Liquorice i...
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| Format: | Article |
| Language: | English |
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2024-01-01
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| Series: | Scripta Medica |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2024/2490-33292406757S.pdf |
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| author | Sanshita Taneja Ayushi Sangnim Tanikan Huanbutta Kampanart Sindhu Rakesh K. Singh Inderbir |
| author_facet | Sanshita Taneja Ayushi Sangnim Tanikan Huanbutta Kampanart Sindhu Rakesh K. Singh Inderbir |
| author_sort | Sanshita |
| collection | DOAJ |
| description | In recent times, individuals are focusing more on natural substances, primarily due to their safety and non-toxicity. Also, there is an increasing demand by industries for the phytoconstituents that might be incorporated in pharmaceuticals, cosmetics, dietary products and nutraceuticals. Liquorice is one of the widely used Chinese herb since ancient times due to its medicinal properties. It exhibits broad spectrum biological activities such as anti-inflammatory, immunomodulatory, anti-oxidant, anti-cancer, anti-diabetic, anti-microbial properties and is used in the treatment of different diseases such as cancer, inflammation, viral infections, cardiovascular and respiratory disorders. Different novel formulations such as nanoparticles, microparticles, liposomes, nanomicells and self-emulsifying drug delivery system are developed that overcome major limitations of liquorice including its low solubility, stability and less bioavailability. In this review, liquorice's historical background, pharmacokinetics, therapeutic applications, different mechanism of actions is discussed with major emphasis on liquorice encapsulated novel formulations (nanoparticles, nanomicelles, liposomes, niosomes, microparticles, microspheres, self-nanoemulsifying system, self-micro-emulsifying system). Liquorice, a prominent constituent of different dietary products, has aroused the interest of many researchers because of its anti-proliferative capacity, tumour microenvironment manipulation and autophagy activation in numerous cancer types. Nanotechnology-based techniques for enhanced solubilisation, stability and targeted drug delivery have been tested by formulation scientists. Liquorice is enclosed in different novel carriers and encapsulated liquorice displayed enhanced stability, solubility, high encapsulation efficiency, controlled drug release and extended circulation time period. |
| format | Article |
| id | doaj-art-b1b4c114652b4021b8157a0946efad6e |
| institution | Kabale University |
| issn | 2490-3329 2303-7954 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj-art-b1b4c114652b4021b8157a0946efad6e2025-02-05T13:19:48ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542024-01-0155675777410.5937/scriptamed55-520242490-33292406757STherapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancementsSanshita0https://orcid.org/0009-0001-6838-7219Taneja Ayushi1https://orcid.org/0000-0002-3534-7704Sangnim Tanikan2https://orcid.org/0000-0002-9332-384XHuanbutta Kampanart3https://orcid.org/0000-0001-8188-153XSindhu Rakesh K.4https://orcid.org/0000-0003-2619-4643Singh Inderbir5https://orcid.org/0000-0002-1860-4246Chitkara University, Chitkara College of Pharmacy, Punjab, IndiaChitkara University, Chitkara College of Pharmacy, Punjab, IndiaBurapha University, Faculty of Pharmaceutical Sciences, Chonburi, ThailandRangsit University, College of Pharmacy, Department of Manufacturing Pharmacy, Pathum Thani, ThailandSharda University, School of Pharmacy, Greater Noida, Uttar Pradesh, IndiaChitkara University, Chitkara College of Pharmacy, Punjab, IndiaIn recent times, individuals are focusing more on natural substances, primarily due to their safety and non-toxicity. Also, there is an increasing demand by industries for the phytoconstituents that might be incorporated in pharmaceuticals, cosmetics, dietary products and nutraceuticals. Liquorice is one of the widely used Chinese herb since ancient times due to its medicinal properties. It exhibits broad spectrum biological activities such as anti-inflammatory, immunomodulatory, anti-oxidant, anti-cancer, anti-diabetic, anti-microbial properties and is used in the treatment of different diseases such as cancer, inflammation, viral infections, cardiovascular and respiratory disorders. Different novel formulations such as nanoparticles, microparticles, liposomes, nanomicells and self-emulsifying drug delivery system are developed that overcome major limitations of liquorice including its low solubility, stability and less bioavailability. In this review, liquorice's historical background, pharmacokinetics, therapeutic applications, different mechanism of actions is discussed with major emphasis on liquorice encapsulated novel formulations (nanoparticles, nanomicelles, liposomes, niosomes, microparticles, microspheres, self-nanoemulsifying system, self-micro-emulsifying system). Liquorice, a prominent constituent of different dietary products, has aroused the interest of many researchers because of its anti-proliferative capacity, tumour microenvironment manipulation and autophagy activation in numerous cancer types. Nanotechnology-based techniques for enhanced solubilisation, stability and targeted drug delivery have been tested by formulation scientists. Liquorice is enclosed in different novel carriers and encapsulated liquorice displayed enhanced stability, solubility, high encapsulation efficiency, controlled drug release and extended circulation time period.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2024/2490-33292406757S.pdfglycyrrhizaliquoriceapplicationsnanoparticlesliposomes |
| spellingShingle | Sanshita Taneja Ayushi Sangnim Tanikan Huanbutta Kampanart Sindhu Rakesh K. Singh Inderbir Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements Scripta Medica glycyrrhiza liquorice applications nanoparticles liposomes |
| title | Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements |
| title_full | Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements |
| title_fullStr | Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements |
| title_full_unstemmed | Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements |
| title_short | Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements |
| title_sort | therapeutic applications of novel drug delivery systems of liquorice an updated review on recent advancements |
| topic | glycyrrhiza liquorice applications nanoparticles liposomes |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2024/2490-33292406757S.pdf |
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