Trehalose Ameliorates Zebrafish Emotional and Social Deficits Caused by CLN8 Dysfunction

Trehalose Ameliorates Zebrafish Emotional and Social Deficits Caused by CLN8 Dysfunction

CLN8 and other neuronal ceroid lipofuscinoses (NCLs) often lead to cognitive decline, emotional disturbances, and social deficits, worsening with disease progression. Disrupted lysosomal pH, impaired autophagy, and defective dendritic arborization contribute to these symptoms. Using a <i>cln8&...

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Bibliographic Details
Main Authors: Rosario Licitra, Stefania Della Vecchia, Lorenzo Santucci, Rachele Vivarelli, Sara Bernardi, Filippo M. Santorelli, Maria Marchese
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
neuronal ceroid lipofuscinoses
CLN8
translational medicine
zebrafish
behavior
trehalose
Online Access:https://www.mdpi.com/2073-4409/14/1/55
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