Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice
Amphipterygium adstringens is an endemic species in Mexico commonly known as “cuachalalate.” Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in m...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/8543561 |
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| author | Mario Rodriguez-Canales Ruben Jimenez-Rivas Maria Margarita Canales-Martinez Ana Judith Garcia-Lopez Nelly Rivera-Yañez Oscar Nieto-Yañez Yadira Ledesma-Soto Luvia Enid Sanchez-Torres Miriam Rodriguez-Sosa Luis Ignacio Terrazas Marco Aurelio Rodriguez-Monroy |
| author_facet | Mario Rodriguez-Canales Ruben Jimenez-Rivas Maria Margarita Canales-Martinez Ana Judith Garcia-Lopez Nelly Rivera-Yañez Oscar Nieto-Yañez Yadira Ledesma-Soto Luvia Enid Sanchez-Torres Miriam Rodriguez-Sosa Luis Ignacio Terrazas Marco Aurelio Rodriguez-Monroy |
| author_sort | Mario Rodriguez-Canales |
| collection | DOAJ |
| description | Amphipterygium adstringens is an endemic species in Mexico commonly known as “cuachalalate.” Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined at 200 mg/kg by oral gavage for 10 days. We determine the effect of AaEE on clinical features (disease activity index), antioxidants, anti-inflammatory, and immunomodulatory activities in relation to the activity of SOD, CAT, and GPx, levels of proinflammatory cytokines, and changes both macroscopic and microscopic of the colonic mucosa. AaEE significantly reduced the inflammation of colon and significantly increased SOD and GPx activities. AaEE also significantly decreased TNF-α, IFN-γ, and IL-1β cytokine levels compared to DSS-treated mice and reduced both infiltration of inflammatory cells and the mucosal damage in colon. The results suggested the protective potential of AaEE in DSS-induced colitis and this might be attributed to its phytochemicals compounds that have been found to induce a wide spectrum of activities such as reduction in oxidative stress, suppression of inflammation, modulating numerous signal transduction pathways, and induction of apoptosis. The findings of this study suggest that AaEE has substantial potential for the treatment of inflammatory colitis. |
| format | Article |
| id | doaj-art-b10aec95c4154b4cb9d52a0a092cad67 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b10aec95c4154b4cb9d52a0a092cad672025-02-03T01:31:00ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/85435618543561Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in MiceMario Rodriguez-Canales0Ruben Jimenez-Rivas1Maria Margarita Canales-Martinez2Ana Judith Garcia-Lopez3Nelly Rivera-Yañez4Oscar Nieto-Yañez5Yadira Ledesma-Soto6Luvia Enid Sanchez-Torres7Miriam Rodriguez-Sosa8Luis Ignacio Terrazas9Marco Aurelio Rodriguez-Monroy10Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n, 11400 Ciudad de México, MexicoLaboratorio de Inmunobiología, Carrera de Medicina, FES Iztacala, UNAM, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoLaboratorio de Farmacognosia, UBIPRO, FES Iztacala, UNAM, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoLaboratorio de Inmunobiología, Carrera de Medicina, FES Iztacala, UNAM, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoLaboratorio de Inmunobiología, Carrera de Medicina, FES Iztacala, UNAM, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoLaboratorio de Inmunobiología, Carrera de Medicina, FES Iztacala, UNAM, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoUnidad de Biomedicina, FES Iztacala, UNAM, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoDepartamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n, 11400 Ciudad de México, MexicoUnidad de Biomedicina, FES Iztacala, UNAM, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoUnidad de Biomedicina, FES Iztacala, UNAM, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoLaboratorio de Inmunobiología, Carrera de Medicina, FES Iztacala, UNAM, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoAmphipterygium adstringens is an endemic species in Mexico commonly known as “cuachalalate.” Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined at 200 mg/kg by oral gavage for 10 days. We determine the effect of AaEE on clinical features (disease activity index), antioxidants, anti-inflammatory, and immunomodulatory activities in relation to the activity of SOD, CAT, and GPx, levels of proinflammatory cytokines, and changes both macroscopic and microscopic of the colonic mucosa. AaEE significantly reduced the inflammation of colon and significantly increased SOD and GPx activities. AaEE also significantly decreased TNF-α, IFN-γ, and IL-1β cytokine levels compared to DSS-treated mice and reduced both infiltration of inflammatory cells and the mucosal damage in colon. The results suggested the protective potential of AaEE in DSS-induced colitis and this might be attributed to its phytochemicals compounds that have been found to induce a wide spectrum of activities such as reduction in oxidative stress, suppression of inflammation, modulating numerous signal transduction pathways, and induction of apoptosis. The findings of this study suggest that AaEE has substantial potential for the treatment of inflammatory colitis.http://dx.doi.org/10.1155/2016/8543561 |
| spellingShingle | Mario Rodriguez-Canales Ruben Jimenez-Rivas Maria Margarita Canales-Martinez Ana Judith Garcia-Lopez Nelly Rivera-Yañez Oscar Nieto-Yañez Yadira Ledesma-Soto Luvia Enid Sanchez-Torres Miriam Rodriguez-Sosa Luis Ignacio Terrazas Marco Aurelio Rodriguez-Monroy Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice Mediators of Inflammation |
| title | Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice |
| title_full | Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice |
| title_fullStr | Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice |
| title_full_unstemmed | Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice |
| title_short | Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice |
| title_sort | protective effect of amphipterygium adstringens extract on dextran sulphate sodium induced ulcerative colitis in mice |
| url | http://dx.doi.org/10.1155/2016/8543561 |
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