Elucidation of Artemisinin as a Potent GSK3β Inhibitor for Neurodegenerative Disorders via Machine Learning-Driven QSAR and Virtual Screening of Natural Compounds

Elucidation of Artemisinin as a Potent GSK3β Inhibitor for Neurodegenerative Disorders via Machine Learning-Driven QSAR and Virtual Screening of Natural Compounds

<b>Background/Objectives:</b> Glycogen synthase kinase-3 beta (GSK3β) is a key enzyme involved in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, contributing to tau hyperphosphorylation, amyloid-beta (Aβ) aggregation, and neuronal dysfunction. <b>Methods</b>:...

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Main Authors: Hassan H. Alhassan, Malvi Surti, Mohd Adnan, Mitesh Patel
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
GSK3β
neurodegenerative diseases
machine learning
artemisinin
QSAR
Online Access:https://www.mdpi.com/1424-8247/18/6/826
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