SYNTHESIS, MOLECULAR DOCKING, DYNAMICS ANALYSIS STUDIES, AND CYTOTOXICITYACTIVITY EVALUATION OF NOVEL BERBERINE DERIVATIVE BEARING OXADIAZOLE AND o-DIAMINOBENZENE MOIETIES

SYNTHESIS, MOLECULAR DOCKING, DYNAMICS ANALYSIS STUDIES, AND CYTOTOXICITYACTIVITY EVALUATION OF NOVEL BERBERINE DERIVATIVE BEARING OXADIAZOLE AND o-DIAMINOBENZENE MOIETIES

Berberine represents a prominent compound with commendable antitumor activity, a novel berberine derivative with substituted o-diaminobenzene moiety linked at the 9-position through oxadiazole and alkyl chain is designed, synthesized by reference to the histone deacetylase (HDAC) inhibitor structure...

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Bibliographic Details
Main Authors: Xiaofei Jiang, Yangming Jiang, Qing Li, Lulin Li, Daoping Wang
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2025-05-01
Series:Química Nova
Subjects:
berberine
synthesis
principle of hybridization
derivative
cytotoxicity activity
molecular docking
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422025000500305&lng=en&tlng=en
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