Altered mitochondrial unfolded protein response and FGF21 secretion in MASLD progression and the effect of exercise intervention

Altered mitochondrial unfolded protein response and FGF21 secretion in MASLD progression and the effect of exercise intervention

Abstract A high-calorie diet and lack of exercise are the most important risk factors contributing to metabolic dysfunction-associated steatotic liver disease (MASLD) initiation and progression. The precise molecular mechanisms of mitochondrial function alteration during MASLD development remain to...

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Bibliographic Details
Main Authors: Xinmeng Yuan, Wen Sun, Ye Xu, Mengqi Xiang, Yaran Gao, Wanyu Feng, Hongjian Xiao, Liumei Zhang, Qiang Tang, Jiao Lu, Yuan Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Mitochondrial unfolded protein response
Hepatic lipid accumulation
Exercise intervention
AMLN diet
MASLD progression
Online Access:https://doi.org/10.1038/s41598-025-87190-6
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