Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.

Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.

<h4>Objective</h4>Application of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupled receptor, is a target of 3-T1AM. However, 3-T1AM effects still persist in mTaar1 knocko...

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Main Authors: Juliane Dinter, Jessica Mühlhaus, Carolin Leonie Wienchol, Chun-Xia Yi, Daniela Nürnberg, Silke Morin, Annette Grüters, Josef Köhrle, Torsten Schöneberg, Matthias Tschöp, Heiko Krude, Gunnar Kleinau, Heike Biebermann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117774&type=printable
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