Starvation-induced metabolic rewiring affects mTORC1 composition in vivo

Abstract Lysosomes play a crucial role in metabolic adaptation to starvation, but detailed in vivo studies are scarce. Therefore, we investigated the changes of the proteome of liver lysosomes in mice starved short-term for 6h or long-term for 24h. We verified starvation-induced catabolism by weight...

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Bibliographic Details
Main Authors: Edgar Kaade, Simone Mausbach, Nina Erps, Marc Sylvester, Farhad Shakeri, Ron D. Jachimowicz, Volkmar Gieselmann, Melanie Thelen
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-78873-7
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