On the MTD paradigm and optimal control for multi-drug cancer chemotherapy
In standard chemotherapy protocols, drugs are given at maximum tolerated doses(MTD) with rest periods in between. In this paper, we briefly discuss therationale behind this therapy approach and, using as examplemulti-drug cancer chemotherapy with a cytotoxic and cytostatic agent, show thatthese type...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2013-03-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.803 |
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