Molecular signatures of invasive and non-invasive pituitary adenomas: a comprehensive analysis of DNA methylation and gene expression

Molecular signatures of invasive and non-invasive pituitary adenomas: a comprehensive analysis of DNA methylation and gene expression

Abstract Background Pituitary adenomas (PAs) are benign tumors in the pituitary gland. However, 30–40% of these tumors are invasive, complicating diagnosis and treatment. Invasive pituitary adenomas (IPAs) often respond poorly to conventional therapies, emphasizing the need for better diagnostic and...

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Main Authors: Yike Chen, Ningning Zhao, Jiahao Zhang, Xinyi Wu, Jian Huang, Xiaohui Xu, Feng Cai, Sheng Chen, Liyin Xu, Wei Yan, Yuan Hong, Yunfei Wang, Hui Ling, Jianxiong Ji, Gao Chen, Hongcang Gu, Jianmin Zhang, Qun Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Invasive pituitary adenoma (IPA)
Pituitary adenoma (PA)
DNA methylation
Cell-free DNA
Reduced representation bisulfite sequencing (RRBS)
Online Access:https://doi.org/10.1186/s12916-025-04164-1
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https://doi.org/10.1186/s12916-025-04164-1

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