Therapeutic potential of formononetin in cirrhotic portal hypertension: modulating hepatic fibrosis, macrophage polarization, and lymphangiogenesis

Therapeutic potential of formononetin in cirrhotic portal hypertension: modulating hepatic fibrosis, macrophage polarization, and lymphangiogenesis

IntroductionFormononetin regulates intrahepatic fibrogenesis and macrophage polarization to improve portal pressure and liver function in rats with cirrhotic PHT through SMAD3, STAT1, STAT3 and GSK-3β signaling pathways, and modulates lymphangiogenesis through direct action and macrophage polarizati...

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Main Authors: Zhenghao Wu, Guqing Luo, Hongjie Li, Min Chen, Guangbo Wu, Qiang Fan, Chihao Zhang, Jiwei Yu, Jiayun Lin, Jinbo Zhao, Xiaoliang Qi, Haizhong Huo, Meng Luo, Lei Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
portal hypertension
liver cirrhosis
macrophages polarization
lymphangiogenesis
formononetin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571007/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571007/full

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