Muscone suppresses inflammation and senescence of nucleus pulposus via p53 signalling during intervertebral disc degeneration

Muscone suppresses inflammation and senescence of nucleus pulposus via p53 signalling during intervertebral disc degeneration

Abstract Intervertebral disc degeneration (IDD) is a major cause of chronic low back pain, the mechanism of which is still unclear. Inflammation-induced extracellular matrix metabolism (ECM) dysregulation in the nucleus pulposus (NP) and NP cell senescence are known to be the key causes of IDD. Howe...

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Main Authors: Ruizhe Wang, Zifan Zhang, Jinhai Xu, Ye Tian, Guoqing Wen, Huajian Zhong, Leixin Wei, Huiqiao Wu, Xiaolong Shen, Yu Chen, Peng Cao, Yang Liu, Huajiang Chen, Chen Xu, Wen Mo, Wen Yuan
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Intervertebral disc degeneration
Nucleus pulposus
Extracellular matrix metabolism
Muscone
p53
Online Access:https://doi.org/10.1038/s41598-025-15811-1
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https://doi.org/10.1038/s41598-025-15811-1

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