Patterns of multimorbidity in primary care electronic health records: A systematic review

Background Multimorbidity, the coexistence of multiple chronic conditions in an individual, is a complex phenomenon that is highly prevalent in primary care settings, particularly in older individuals. This systematic review summarises the current evidence on multimorbidity patterns identified in pr...

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Main Authors: Giorgi Beridze, Ahmad Abbadi, Joan Ars, Francesca Remelli, Davide L Vetrano, Caterina Trevisan, Laura-Mónica Pérez, Juan A López-Rodríguez, Amaia Calderón-Larrañaga
Format: Article
Language:English
Published: SAGE Publishing 2024-01-01
Series:Journal of Multimorbidity and Comorbidity
Online Access:https://doi.org/10.1177/26335565231223350
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author Giorgi Beridze
Ahmad Abbadi
Joan Ars
Francesca Remelli
Davide L Vetrano
Caterina Trevisan
Laura-Mónica Pérez
Juan A López-Rodríguez
Amaia Calderón-Larrañaga
author_facet Giorgi Beridze
Ahmad Abbadi
Joan Ars
Francesca Remelli
Davide L Vetrano
Caterina Trevisan
Laura-Mónica Pérez
Juan A López-Rodríguez
Amaia Calderón-Larrañaga
author_sort Giorgi Beridze
collection DOAJ
description Background Multimorbidity, the coexistence of multiple chronic conditions in an individual, is a complex phenomenon that is highly prevalent in primary care settings, particularly in older individuals. This systematic review summarises the current evidence on multimorbidity patterns identified in primary care electronic health record (EHR) data. Methods Three databases were searched from inception to April 2022 to identify studies that derived original multimorbidity patterns from primary care EHR data. The quality of the included studies was assessed using a modified version of the Newcastle-Ottawa Quality Assessment Scale. Results Sixteen studies were included in this systematic review, none of which was of low quality. Most studies were conducted in Spain, and only one study was conducted outside of Europe. The prevalence of multimorbidity (i.e. two or more conditions) ranged from 14.0% to 93.9%. The most common stratification variable in disease clustering models was sex, followed by age and calendar year. Despite significant heterogeneity in clustering methods and disease classification tools, consistent patterns of multimorbidity emerged. Mental health and cardiovascular patterns were identified in all studies, often in combination with diseases of other organ systems (e.g. neurological, endocrine). Discussion These findings emphasise the frequent coexistence of physical and mental health conditions in primary care, and provide useful information for the development of targeted preventive and management strategies. Future research should explore mechanisms underlying multimorbidity patterns, prioritise methodological harmonisation to facilitate the comparability of findings, and promote the use of EHR data globally to enhance our understanding of multimorbidity in more diverse populations.
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spelling doaj-art-b030a937d18d4ca981743595c88dbfe32025-01-30T17:03:21ZengSAGE PublishingJournal of Multimorbidity and Comorbidity2633-55652024-01-011410.1177/26335565231223350Patterns of multimorbidity in primary care electronic health records: A systematic reviewGiorgi BeridzeAhmad AbbadiJoan ArsFrancesca RemelliDavide L VetranoCaterina TrevisanLaura-Mónica PérezJuan A López-RodríguezAmaia Calderón-LarrañagaBackground Multimorbidity, the coexistence of multiple chronic conditions in an individual, is a complex phenomenon that is highly prevalent in primary care settings, particularly in older individuals. This systematic review summarises the current evidence on multimorbidity patterns identified in primary care electronic health record (EHR) data. Methods Three databases were searched from inception to April 2022 to identify studies that derived original multimorbidity patterns from primary care EHR data. The quality of the included studies was assessed using a modified version of the Newcastle-Ottawa Quality Assessment Scale. Results Sixteen studies were included in this systematic review, none of which was of low quality. Most studies were conducted in Spain, and only one study was conducted outside of Europe. The prevalence of multimorbidity (i.e. two or more conditions) ranged from 14.0% to 93.9%. The most common stratification variable in disease clustering models was sex, followed by age and calendar year. Despite significant heterogeneity in clustering methods and disease classification tools, consistent patterns of multimorbidity emerged. Mental health and cardiovascular patterns were identified in all studies, often in combination with diseases of other organ systems (e.g. neurological, endocrine). Discussion These findings emphasise the frequent coexistence of physical and mental health conditions in primary care, and provide useful information for the development of targeted preventive and management strategies. Future research should explore mechanisms underlying multimorbidity patterns, prioritise methodological harmonisation to facilitate the comparability of findings, and promote the use of EHR data globally to enhance our understanding of multimorbidity in more diverse populations.https://doi.org/10.1177/26335565231223350
spellingShingle Giorgi Beridze
Ahmad Abbadi
Joan Ars
Francesca Remelli
Davide L Vetrano
Caterina Trevisan
Laura-Mónica Pérez
Juan A López-Rodríguez
Amaia Calderón-Larrañaga
Patterns of multimorbidity in primary care electronic health records: A systematic review
Journal of Multimorbidity and Comorbidity
title Patterns of multimorbidity in primary care electronic health records: A systematic review
title_full Patterns of multimorbidity in primary care electronic health records: A systematic review
title_fullStr Patterns of multimorbidity in primary care electronic health records: A systematic review
title_full_unstemmed Patterns of multimorbidity in primary care electronic health records: A systematic review
title_short Patterns of multimorbidity in primary care electronic health records: A systematic review
title_sort patterns of multimorbidity in primary care electronic health records a systematic review
url https://doi.org/10.1177/26335565231223350
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