10-Year Results of Standard Cross-Linking in Patients with Progressive Keratoconus in Romania
Purpose. The purpose of the current study was to evaluate the long-term functional results based on keratometric measurements, spherical and cylinder equivalent in patients with progressive keratoconus treated with conventional “epi-off” corneal collagen cross-linking (CXL). Methods. We conducted a...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/8285649 |
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| author | Cristina Nicula Radu Pop Anca Rednik Dorin Nicula |
| author_facet | Cristina Nicula Radu Pop Anca Rednik Dorin Nicula |
| author_sort | Cristina Nicula |
| collection | DOAJ |
| description | Purpose. The purpose of the current study was to evaluate the long-term functional results based on keratometric measurements, spherical and cylinder equivalent in patients with progressive keratoconus treated with conventional “epi-off” corneal collagen cross-linking (CXL). Methods. We conducted a retrospective study in which 113 eyes from 90 keratoconus-treated patients with CXL between 2006 and 2008 in Oculens Eye Clinic from Cluj-Napoca, Romania, were included. The diagnosis of keratoconus was based on corneal topography and its clinical signs. All patients were evaluated preoperatively, and a follow-up was performed at 1, 3, and 6 months and every year from 1 to 10 years after conventional CXL. Results. All keratometry measurements improved significantly during the follow-up. Compared to preoperative values, the improvement of Kmax become statistically significant at 1 year after CXL (mean change compared to baseline −0.9 D, p<0.001) and remained statistically significant thereafter up to 10 years (mean change compared to baseline −2.3 D, p<0.001). As compared to preoperative values, mean spherical equivalent and mean cylinder improved during the follow-up, from a mean of −6.22 D before CXL to a mean value of −5.0 at 10 years, following CXL for spherical equivalent and from −4.4 D at baseline to −3.4 D at 10 years for cylinder (p<0.05 for both). Uncorrected visual acuity increased, remaining statistically significant, by 0.104 logMAR at 10 years after CXL (p=0.0015), and best-corrected visual acuity increased by 0.135 logMAR at 10 years after CXL (p=0.015). We did not observe any case of severe complication. Conclusion. Our results show that CXL has a favorable effect on the progression of KC. The reduced K values, cylinder and spherical equivalent, and increased visual acuity remained the same 10 years after the procedure. |
| format | Article |
| id | doaj-art-b00c6efa3fbb487b93a89f1ff6899651 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-b00c6efa3fbb487b93a89f1ff68996512025-02-03T01:11:44ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/8285649828564910-Year Results of Standard Cross-Linking in Patients with Progressive Keratoconus in RomaniaCristina Nicula0Radu Pop1Anca Rednik2Dorin Nicula3University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, RomaniaOculens Clinic, Cluj-Napoca, RomaniaEye Clinic, Emergency Clinical County Hospital, Cluj-Napoca, RomaniaOculens Clinic, Cluj-Napoca, RomaniaPurpose. The purpose of the current study was to evaluate the long-term functional results based on keratometric measurements, spherical and cylinder equivalent in patients with progressive keratoconus treated with conventional “epi-off” corneal collagen cross-linking (CXL). Methods. We conducted a retrospective study in which 113 eyes from 90 keratoconus-treated patients with CXL between 2006 and 2008 in Oculens Eye Clinic from Cluj-Napoca, Romania, were included. The diagnosis of keratoconus was based on corneal topography and its clinical signs. All patients were evaluated preoperatively, and a follow-up was performed at 1, 3, and 6 months and every year from 1 to 10 years after conventional CXL. Results. All keratometry measurements improved significantly during the follow-up. Compared to preoperative values, the improvement of Kmax become statistically significant at 1 year after CXL (mean change compared to baseline −0.9 D, p<0.001) and remained statistically significant thereafter up to 10 years (mean change compared to baseline −2.3 D, p<0.001). As compared to preoperative values, mean spherical equivalent and mean cylinder improved during the follow-up, from a mean of −6.22 D before CXL to a mean value of −5.0 at 10 years, following CXL for spherical equivalent and from −4.4 D at baseline to −3.4 D at 10 years for cylinder (p<0.05 for both). Uncorrected visual acuity increased, remaining statistically significant, by 0.104 logMAR at 10 years after CXL (p=0.0015), and best-corrected visual acuity increased by 0.135 logMAR at 10 years after CXL (p=0.015). We did not observe any case of severe complication. Conclusion. Our results show that CXL has a favorable effect on the progression of KC. The reduced K values, cylinder and spherical equivalent, and increased visual acuity remained the same 10 years after the procedure.http://dx.doi.org/10.1155/2019/8285649 |
| spellingShingle | Cristina Nicula Radu Pop Anca Rednik Dorin Nicula 10-Year Results of Standard Cross-Linking in Patients with Progressive Keratoconus in Romania Journal of Ophthalmology |
| title | 10-Year Results of Standard Cross-Linking in Patients with Progressive Keratoconus in Romania |
| title_full | 10-Year Results of Standard Cross-Linking in Patients with Progressive Keratoconus in Romania |
| title_fullStr | 10-Year Results of Standard Cross-Linking in Patients with Progressive Keratoconus in Romania |
| title_full_unstemmed | 10-Year Results of Standard Cross-Linking in Patients with Progressive Keratoconus in Romania |
| title_short | 10-Year Results of Standard Cross-Linking in Patients with Progressive Keratoconus in Romania |
| title_sort | 10 year results of standard cross linking in patients with progressive keratoconus in romania |
| url | http://dx.doi.org/10.1155/2019/8285649 |
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