Four-dimensional, dynamic mosaicism is a hallmark of normal human skin that permits mapping of the organization and patterning of human epidermis during terminal differentiation.

Four-dimensional, dynamic mosaicism is a hallmark of normal human skin that permits mapping of the organization and patterning of human epidermis during terminal differentiation.

Recent findings of mosaicism (DNA sequence variation) challenge the dogma that each person has a stable genetic constitution. Copy number variations, point mutations and chromosome abnormalities in normal or diseased tissues have been described. We studied normal skin mosaicism of a single nucleotid...

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Main Authors: Yun Wang, Taro Masaki, Sikandar G Khan, Deborah Tamura, Christiane Kuschal, Megan Rogers, John J DiGiovanna, Kenneth H Kraemer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198011/1/pone.0198011.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T092039Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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