Combined lung and liver transplant for cirrhosis, idiopathic pulmonary fibrosis, and hemophilia A: Case report
Combined lung and liver transplantation (CLLT) is a rare intervention for end-stage lung and liver diseases. It poses a challenge for patients with increased bleeding risk due to Hemophilia A and liver coagulopathy. We present the first documented case of CLLT in an elderly male with Hemophilia A, H...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Transplantation Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451959624000143 |
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| author | Lorenzo Olivero Hong Liang Ian A. Makey Si M. Pham Jorge Sinclair Stephen Aniskevich, III Sadia Z. Shah Dana K. Perry Wesley L. Allen Nathan H. Waldron Liu Yang Pramod K. Guru Candido E. Rivera Pablo Moreno Franco Tathagat Narula |
| author_facet | Lorenzo Olivero Hong Liang Ian A. Makey Si M. Pham Jorge Sinclair Stephen Aniskevich, III Sadia Z. Shah Dana K. Perry Wesley L. Allen Nathan H. Waldron Liu Yang Pramod K. Guru Candido E. Rivera Pablo Moreno Franco Tathagat Narula |
| author_sort | Lorenzo Olivero |
| collection | DOAJ |
| description | Combined lung and liver transplantation (CLLT) is a rare intervention for end-stage lung and liver diseases. It poses a challenge for patients with increased bleeding risk due to Hemophilia A and liver coagulopathy. We present the first documented case of CLLT in an elderly male with Hemophilia A, HCV-associated cirrhosis, and Idiopathic Pulmonary Fibrosis (IPF). Despite the patient exhibiting stable liver function and hemophilia, his lung condition rapidly deteriorated, prompting the listing for transplant. The patient underwent a successful CLLT with perioperative management coordinated by the multidisciplinary team to address the unique challenges of Hemophilia A, resulting in intra-operative correction of coagulopathy. The patient exhibited a favorable recovery, with no requirement for Factor FVIII replacement therapy postoperatively. This case demonstrates that CLLT can address three diseases with distinct pathophysiologies: end-stage lung and liver disease, and correct the hemophilia A phenotype. Our report contributes to the limited literature on the suitability of CLLT in patients with hemophilia A. |
| format | Article |
| id | doaj-art-aff861885b1d42a2bc9b6416fa9eb061 |
| institution | OA Journals |
| issn | 2451-9596 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Transplantation Reports |
| spelling | doaj-art-aff861885b1d42a2bc9b6416fa9eb0612025-08-20T01:56:45ZengElsevierTransplantation Reports2451-95962024-12-019410016310.1016/j.tpr.2024.100163Combined lung and liver transplant for cirrhosis, idiopathic pulmonary fibrosis, and hemophilia A: Case reportLorenzo Olivero0Hong Liang1Ian A. Makey2Si M. Pham3Jorge Sinclair4Stephen Aniskevich, III5Sadia Z. Shah6Dana K. Perry7Wesley L. Allen8Nathan H. Waldron9Liu Yang10Pramod K. Guru11Candido E. Rivera12Pablo Moreno Franco13Tathagat Narula14Department of Critical Care, Mayo Clinic, Jacksonville, FL, USA; Jacobi Medical Center/Albert Einstein College of Medicine, New York, NY, USADepartment of Anesthesiology, Mayo Clinic, Jacksonville, FL, USADepartment of Cardiovascular and Thoracic Surgery, Mayo Clinic, Jacksonville, FL, USADepartment of Cardiovascular and Thoracic Surgery, Mayo Clinic, Jacksonville, FL, USADepartment of Critical Care, Mayo Clinic, Jacksonville, FL, USA; Mount Sinai Morningside and Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Anesthesiology, Mayo Clinic, Jacksonville, FL, USADepartment of Transplant, Mayo Clinic, Jacksonville, FL, USADepartment of Transplant, Mayo Clinic, Jacksonville, FL, USADepartment of Anesthesiology, Mayo Clinic, Jacksonville, FL, USADepartment of Critical Care, Mayo Clinic, Jacksonville, FL, USA; Department of Anesthesiology, Mayo Clinic, Jacksonville, FL, USADepartment of Transplant, Mayo Clinic, Jacksonville, FL, USADepartment of Critical Care, Mayo Clinic, Jacksonville, FL, USA; Department of Transplant, Mayo Clinic, Jacksonville, FL, USADepartment of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USADepartment of Critical Care, Mayo Clinic, Jacksonville, FL, USA; Department of Transplant, Mayo Clinic, Jacksonville, FL, USA; Corresponding author at: Department of Critical Care Medicine, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL 32224, USA.Department of Transplant, Mayo Clinic, Jacksonville, FL, USACombined lung and liver transplantation (CLLT) is a rare intervention for end-stage lung and liver diseases. It poses a challenge for patients with increased bleeding risk due to Hemophilia A and liver coagulopathy. We present the first documented case of CLLT in an elderly male with Hemophilia A, HCV-associated cirrhosis, and Idiopathic Pulmonary Fibrosis (IPF). Despite the patient exhibiting stable liver function and hemophilia, his lung condition rapidly deteriorated, prompting the listing for transplant. The patient underwent a successful CLLT with perioperative management coordinated by the multidisciplinary team to address the unique challenges of Hemophilia A, resulting in intra-operative correction of coagulopathy. The patient exhibited a favorable recovery, with no requirement for Factor FVIII replacement therapy postoperatively. This case demonstrates that CLLT can address three diseases with distinct pathophysiologies: end-stage lung and liver disease, and correct the hemophilia A phenotype. Our report contributes to the limited literature on the suitability of CLLT in patients with hemophilia A.http://www.sciencedirect.com/science/article/pii/S2451959624000143Liver transplantationLung transplantationHemophilia aCase report |
| spellingShingle | Lorenzo Olivero Hong Liang Ian A. Makey Si M. Pham Jorge Sinclair Stephen Aniskevich, III Sadia Z. Shah Dana K. Perry Wesley L. Allen Nathan H. Waldron Liu Yang Pramod K. Guru Candido E. Rivera Pablo Moreno Franco Tathagat Narula Combined lung and liver transplant for cirrhosis, idiopathic pulmonary fibrosis, and hemophilia A: Case report Transplantation Reports Liver transplantation Lung transplantation Hemophilia a Case report |
| title | Combined lung and liver transplant for cirrhosis, idiopathic pulmonary fibrosis, and hemophilia A: Case report |
| title_full | Combined lung and liver transplant for cirrhosis, idiopathic pulmonary fibrosis, and hemophilia A: Case report |
| title_fullStr | Combined lung and liver transplant for cirrhosis, idiopathic pulmonary fibrosis, and hemophilia A: Case report |
| title_full_unstemmed | Combined lung and liver transplant for cirrhosis, idiopathic pulmonary fibrosis, and hemophilia A: Case report |
| title_short | Combined lung and liver transplant for cirrhosis, idiopathic pulmonary fibrosis, and hemophilia A: Case report |
| title_sort | combined lung and liver transplant for cirrhosis idiopathic pulmonary fibrosis and hemophilia a case report |
| topic | Liver transplantation Lung transplantation Hemophilia a Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2451959624000143 |
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