Danshen injection ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibiting ferroptosis via activating SIRT1/GPX4 pathway

Danshen injection ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibiting ferroptosis via activating SIRT1/GPX4 pathway

IntroductionThe pathogenesis of renal fibrosis is related to blood stasis, and the method of promoting blood circulation and removing blood stasis is often used as the treatment principle. Danshen injection (DSI) is a commonly used drug for promoting blood circulation and removing blood stasis in cl...

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Main Authors: Yiwen Cao, Huan Zhao, Shuyin Lin, Junqi Chen, Jingli Xiong, Zhijun Zeng, Ziyu Long, Yingru Su, Yingqi Zhong, Lingru Zhao, Mingshan Zhang, Junbiao Wu, Yuan Zhou, Jiuyao Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
danshen injection
renal fibrosis
ferroptosis
SIRT1
GPX4
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1503628/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1503628/full

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