Insights into the mechanisms, regulation, and therapeutic implications of extracellular matrix stiffness in cancer

Insights into the mechanisms, regulation, and therapeutic implications of extracellular matrix stiffness in cancer

Abstract The tumor microenvironment (TME) is critical for cancer initiation, growth, metastasis, and therapeutic resistance. The extracellular matrix (ECM) is a significant tumor component that serves various functions, including mechanical support, TME regulation, and signal molecule generation. Th...

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Bibliographic Details
Main Authors: Ximo Zhang, Abdullah Al‐Danakh, Xinqing Zhu, Dan Feng, Linlin Yang, Haotian Wu, Yingying Li, Shujing Wang, Qiwei Chen, Deyong Yang
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Bioengineering & Translational Medicine
Subjects:
cancer
ECM stiffness
extracellular matrix
signaling pathways
targeted therapy
tumor microenvironment
Online Access:https://doi.org/10.1002/btm2.10698
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https://doi.org/10.1002/btm2.10698

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