Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder
Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of individuals worldwide. Although the biogenic amine model has provided some clinical utility, a need remains to better understand the interrelated mechanisms that contribute to neuroplasticity deficits in MDs and the...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/7014146 |
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| _version_ | 1832549817090310144 |
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| author | Cristy Phillips |
| author_facet | Cristy Phillips |
| author_sort | Cristy Phillips |
| collection | DOAJ |
| description | Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of individuals worldwide. Although the biogenic amine model has provided some clinical utility, a need remains to better understand the interrelated mechanisms that contribute to neuroplasticity deficits in MDs and the means by which various therapeutics mitigate them. Of those therapeutics being investigated, physical activity (PA) has shown clear and consistent promise. Accordingly, the aims of this review are to (1) explicate key modulators, processes, and interactions that impinge upon multiple susceptibility points to effectuate neuroplasticity deficits in MDs; (2) explore the putative mechanisms by which PA mitigates these features; (3) review protocols used to induce the positive effects of PA in MDs; and (4) highlight implications for clinicians and researchers. |
| format | Article |
| id | doaj-art-afc1d41626e6486ba3a2cb8531cdfd39 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-afc1d41626e6486ba3a2cb8531cdfd392025-02-03T06:08:32ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/70141467014146Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar DisorderCristy Phillips0Department of Physical Therapy, A-State, Jonesboro, AR, USAMood disorders (MDs) are chronic, recurrent mental diseases that affect millions of individuals worldwide. Although the biogenic amine model has provided some clinical utility, a need remains to better understand the interrelated mechanisms that contribute to neuroplasticity deficits in MDs and the means by which various therapeutics mitigate them. Of those therapeutics being investigated, physical activity (PA) has shown clear and consistent promise. Accordingly, the aims of this review are to (1) explicate key modulators, processes, and interactions that impinge upon multiple susceptibility points to effectuate neuroplasticity deficits in MDs; (2) explore the putative mechanisms by which PA mitigates these features; (3) review protocols used to induce the positive effects of PA in MDs; and (4) highlight implications for clinicians and researchers.http://dx.doi.org/10.1155/2017/7014146 |
| spellingShingle | Cristy Phillips Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder Neural Plasticity |
| title | Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder |
| title_full | Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder |
| title_fullStr | Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder |
| title_full_unstemmed | Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder |
| title_short | Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder |
| title_sort | physical activity modulates common neuroplasticity substrates in major depressive and bipolar disorder |
| url | http://dx.doi.org/10.1155/2017/7014146 |
| work_keys_str_mv | AT cristyphillips physicalactivitymodulatescommonneuroplasticitysubstratesinmajordepressiveandbipolardisorder |