Diagnostic Accuracy of Urinary Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis
Background. Biomarkers can be measured in various biological samples. Urine is among the most useful biofluids for routine testing, and several experimental and clinical studies support its role as a tool for the diagnosis and prevention of various diseases. The present systematic review aimed to ex...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2024/9769772 |
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| author | Adriano Fratini Rossana Izzetti Nicola Riccetti Stefano Gennai Filippo Graziani Enrico Marchetti |
| author_facet | Adriano Fratini Rossana Izzetti Nicola Riccetti Stefano Gennai Filippo Graziani Enrico Marchetti |
| author_sort | Adriano Fratini |
| collection | DOAJ |
| description | Background. Biomarkers can be measured in various biological samples. Urine is among the most useful biofluids for routine testing, and several experimental and clinical studies support its role as a tool for the diagnosis and prevention of various diseases. The present systematic review aimed to examine periodontitis-specific urine biomarkers that could have a diagnostic relevance and to provide a qualitative assessment of the current literature. Materials and Methods. Relevant studies identified from PubMed, Embase, Cochrane Library, and Scopus databases were examined to answer the following PECO question: “Could the concentration of specific metabolites in the urine be related to periodontal health and what is their diagnostic accuracy?”. Quality of included studies was rated using ROBINS-I tool. Meta-analysis was conducted on available quantitative data. Results. After the screening of 768 titles, five studies were included in qualitative synthesis. The studies included referred to the evaluation of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and neopterin. Meta-analysis was conducted for neopterin concentration on data available in four studies involving 129 participants. Higher concentrations of neopterin were found in periodontitis-affected patients compared to controls and patients treated for periodontitis. Conclusions. The literature appears controversial in attributing a role to neopterin and 8-OHdG as periodontal biomarkers, highlighting the need for further clinical studies on this topic. While some studies report variations in 8-OHdG and neopterin levels in periodontally affected patients versus either controls or periodontally treated patients, the level of evidence appears still limited to draw firm conclusions (PROSPERO CRD42020222681). |
| format | Article |
| id | doaj-art-afbe87c2d266440bb52b240f5a4f18c7 |
| institution | Kabale University |
| issn | 1687-8736 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-afbe87c2d266440bb52b240f5a4f18c72025-02-03T05:54:42ZengWileyInternational Journal of Dentistry1687-87362024-01-01202410.1155/2024/9769772Diagnostic Accuracy of Urinary Biomarkers in Periodontitis: A Systematic Review and Meta-AnalysisAdriano Fratini0Rossana Izzetti1Nicola Riccetti2Stefano Gennai3Filippo Graziani4Enrico Marchetti5Department of Life, Health and Environmental SciencesDepartment of Surgical, Medical and Molecular Pathology and Critical Care MedicineInstitute of Medical BiostatisticsDepartment of Surgical, Medical and Molecular Pathology and Critical Care MedicineDepartment of Surgical, Medical and Molecular Pathology and Critical Care MedicineDepartment of Life, Health and Environmental SciencesBackground. Biomarkers can be measured in various biological samples. Urine is among the most useful biofluids for routine testing, and several experimental and clinical studies support its role as a tool for the diagnosis and prevention of various diseases. The present systematic review aimed to examine periodontitis-specific urine biomarkers that could have a diagnostic relevance and to provide a qualitative assessment of the current literature. Materials and Methods. Relevant studies identified from PubMed, Embase, Cochrane Library, and Scopus databases were examined to answer the following PECO question: “Could the concentration of specific metabolites in the urine be related to periodontal health and what is their diagnostic accuracy?”. Quality of included studies was rated using ROBINS-I tool. Meta-analysis was conducted on available quantitative data. Results. After the screening of 768 titles, five studies were included in qualitative synthesis. The studies included referred to the evaluation of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and neopterin. Meta-analysis was conducted for neopterin concentration on data available in four studies involving 129 participants. Higher concentrations of neopterin were found in periodontitis-affected patients compared to controls and patients treated for periodontitis. Conclusions. The literature appears controversial in attributing a role to neopterin and 8-OHdG as periodontal biomarkers, highlighting the need for further clinical studies on this topic. While some studies report variations in 8-OHdG and neopterin levels in periodontally affected patients versus either controls or periodontally treated patients, the level of evidence appears still limited to draw firm conclusions (PROSPERO CRD42020222681).http://dx.doi.org/10.1155/2024/9769772 |
| spellingShingle | Adriano Fratini Rossana Izzetti Nicola Riccetti Stefano Gennai Filippo Graziani Enrico Marchetti Diagnostic Accuracy of Urinary Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis International Journal of Dentistry |
| title | Diagnostic Accuracy of Urinary Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis |
| title_full | Diagnostic Accuracy of Urinary Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis |
| title_fullStr | Diagnostic Accuracy of Urinary Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Diagnostic Accuracy of Urinary Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis |
| title_short | Diagnostic Accuracy of Urinary Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis |
| title_sort | diagnostic accuracy of urinary biomarkers in periodontitis a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2024/9769772 |
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