Biomarkers for an early diagnosis of immune effector cell associated-hemophagocytic syndrome

Biomarkers for an early diagnosis of immune effector cell associated-hemophagocytic syndrome

Hemophagocytic lymphohistiocytosis (HLH) is a hyper-inflammatory syndrome characterized by deficient NK-cell activity, cytokine storm and altered T-cell immunity, potentially sustained by multiple triggers. Recently, a hyperinflammatory condition resembling HLH has emerged as a potential complicatio...

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Main Authors: Edoardo Campodonico, Piera Angelillo, Matteo Doglio, Alessia Ugolini, Maria Teresa Lupo Stanghellini, Maddalena Noviello, Elena Tassi, Federica Pedica, Gregorio Maria Bergonzi, Lorenzo Lazzari, Alessandro Bruno, Elisa Diral, Maurilio Ponzoni, Consuelo Corti, Jacopo Peccatori, Annalisa Ruggeri, Andrés José Marìa Ferreri, Chiara Bonini, Fabio Ciceri, Matteo G. Carrabba, Raffaella Greco
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
CAR (chimeric antigen receptor) T cells
B cell lymphoma
HLH - hemophagocytic lymphohistiocytosis
biomarkers
hyperinflammation
IEC-HS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1635062/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1635062/full

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