HBV sequence integrated to enhancer acting as oncogenic driver epigenetically promotes hepatocellular carcinoma development

HBV sequence integrated to enhancer acting as oncogenic driver epigenetically promotes hepatocellular carcinoma development

Abstract Background HBV integration is considered as the main contributor to hepatocellular carcinoma (HCC). However, whether HBV integrated sequences determine genotype pathogenicity and how to block their function during HCC progression remains unclear. Methods An in vitro HBV-infected PHH model a...

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Bibliographic Details
Main Authors: Lu Chen, Wenxuan Li, Wenjing Zai, Xiangyi Zheng, Xianlong Meng, Qunyan Yao, Wei Li, Ying Liang, Mu Ye, Kaicheng Zhou, Mengxing Liu, Zhicong Yang, Zhanrui Mao, Hongyan Wei, Shuai Yang, Guoming Shi, Zhenghong Yuan, Wenqiang Yu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HBV Sequences Integrated To Enhancer (HBV-SITEs)
Nuclear activating miRNA
Enhancer
Hepatocellular carcinoma (HCC)
HBV integration
Online Access:https://doi.org/10.1186/s13046-025-03413-8
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https://doi.org/10.1186/s13046-025-03413-8

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