Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, rece...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/321209 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563516951756800 |
|---|---|
| author | Emma V. Jones David S. Bouvier |
| author_facet | Emma V. Jones David S. Bouvier |
| author_sort | Emma V. Jones |
| collection | DOAJ |
| description | Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, recent studies have revealed that these molecules may also play instrumental roles in central nervous system (CNS) development and diseases. In this minireview, we discuss the matricellular protein families SPARC (secreted protein acidic and rich in cysteine), Hevin/SC1 (SPARC-like 1), TN-C (Tenascin C), TSP (Thrombospondin), and CCN (CYR61/CTGF/NOV), which are secreted by astrocytes during development. These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry. Conversely, their reexpression in reactive astrocytes may also lead to detrimental effects and promote the progression of neurodegenerative diseases. |
| format | Article |
| id | doaj-art-af9abc9474f44bc0865e3078f23f2104 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-af9abc9474f44bc0865e3078f23f21042025-02-03T01:20:04ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/321209321209Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and DiseaseEmma V. Jones0David S. Bouvier1Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, QC, H3G 1A4, CanadaCentre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, QC, H3G 1A4, CanadaMatricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, recent studies have revealed that these molecules may also play instrumental roles in central nervous system (CNS) development and diseases. In this minireview, we discuss the matricellular protein families SPARC (secreted protein acidic and rich in cysteine), Hevin/SC1 (SPARC-like 1), TN-C (Tenascin C), TSP (Thrombospondin), and CCN (CYR61/CTGF/NOV), which are secreted by astrocytes during development. These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry. Conversely, their reexpression in reactive astrocytes may also lead to detrimental effects and promote the progression of neurodegenerative diseases.http://dx.doi.org/10.1155/2014/321209 |
| spellingShingle | Emma V. Jones David S. Bouvier Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease Neural Plasticity |
| title | Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease |
| title_full | Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease |
| title_fullStr | Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease |
| title_full_unstemmed | Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease |
| title_short | Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease |
| title_sort | astrocyte secreted matricellular proteins in cns remodelling during development and disease |
| url | http://dx.doi.org/10.1155/2014/321209 |
| work_keys_str_mv | AT emmavjones astrocytesecretedmatricellularproteinsincnsremodellingduringdevelopmentanddisease AT davidsbouvier astrocytesecretedmatricellularproteinsincnsremodellingduringdevelopmentanddisease |