Desensitizing Effect of Intra‐Tumoral GDF‐15 on Immunotherapy in Patients With Advanced Non‐Small Cell Lung Cancer

Desensitizing Effect of Intra‐Tumoral GDF‐15 on Immunotherapy in Patients With Advanced Non‐Small Cell Lung Cancer

ABSTRACT Background Serum growth/differentiation factor 15 (GDF‐15) suppresses anti‐tumor immunity and predicts prognosis in several malignancies. Elevated GDF‐15 levels are linked to cancer cachexia, characterized by weight loss and systemic inflammation, adversely affecting patient outcomes and th...

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Main Authors: Naoya Nishioka, Tateaki Naito, Takashi Sugino, Koji Muramatsu, Shigeki Nishihara, Hiroki Urashima, Nobuaki Mamesaya, Haruki Kobayashi, Shota Omori, Ryo Ko, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Toshiaki Takahashi
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Thoracic Cancer
Subjects:
cachexia
GDF‐15
non‐small cell lung cancer
PD‐1/PD‐L1 inhibitors
survival
Online Access:https://doi.org/10.1111/1759-7714.70089
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https://doi.org/10.1111/1759-7714.70089

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