SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL

SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL

Hepatitis C virus (HCV) causes a severe liver disease frequentlyassociatedwith cirrhosis andhepatocellular carcinoma. No effective anti-HCVtherapyis available so far. Thus, it is pertinent to applymathematical modelingto prediction ofthe efficiencyofnew candidate pharmaceuticals. Astochastic mathema...

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Bibliographic Details
Main Authors: E. L. Mishchenko, N. V. Ivanisenko, I. R. Akberdin, P. S. Demenkov, V. A. Likhoshvai, N. A. Kolchanov, V. A. Ivanisenko
Format: Article
Language:English
Published: Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2014-12-01
Series:Вавиловский журнал генетики и селекции
Subjects:
hepatitis c virus
subgenomic replicon
mathematical modeling
effectiveness of drugs
Online Access:https://vavilov.elpub.ru/jour/article/view/50
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