Structure-activity relationship of PET-degrading cutinase regulated by weak Ca2+ binding and temperature

Structure-activity relationship of PET-degrading cutinase regulated by weak Ca2+ binding and temperature

Enzyme function is often regulated by weak metal-ion binding, which results from conformational changes while maintaining conformational fluctuations. We analyzed the structure and function of cutinase-like enzyme, Cut190, using biophysical methods such as X-ray crystallography and molecular dynamic...

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Bibliographic Details
Main Authors: Fumiya Kondo, Narutoshi Kamiya, Gert-Jan Bekker, Satoshi Nagao, Nobutaka Numoto, Hiroshi Sekiguchi, Nobutoshi Ito, Masayuki Oda
Format: Article
Language:English
Published: The Biophysical Society of Japan 2025-05-01
Series:Biophysics and Physicobiology
Subjects:
catalytic activity
conformational change
enzyme
multicanonical molecular dynamics simulations
weak metal-ion binding
Online Access:https://doi.org/10.2142/biophysico.bppb-v22.0009
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https://doi.org/10.2142/biophysico.bppb-v22.0009

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