Dual drug-loaded tumor-targeted polymeric nanoparticles for enhancing therapeutic response in pancreatic ductal adenocarcinoma

Dual drug-loaded tumor-targeted polymeric nanoparticles for enhancing therapeutic response in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease where standard-of-care chemotherapeutic drugs have limited efficacy due to the development of drug resistance and poor drug delivery caused by a highly desmoplastic tumor microenvironment. Combining multiple drugs in a tumor-targeting carri...

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Main Authors: Naga Malleswara Rao Nakka, Hari Krishnareddy Rachamala, Ramcharan Singh Angom, Nagamalleswara Rao Indla, Shamit Kumar Dutta, Enfeng Wang, Santanu Bhattacharya, Annadanam V. Sesha Sainath, Hani Babiker, Krishnendu Pal, Debabrata Mukhopadhyay
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Materials Today Bio
Subjects:
Pancreatic ductal adenocarcinoma
Tumor-targeted therapy
Amphiphilic tri-block copolymer
Gemcitabine
Paclitaxel
Polymer nanoparticles
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424002606
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