Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity
Although neo-antigen mRNA vaccines are promising for personalized cancer therapy, their effectiveness is often limited by the immunosuppressive tumor microenvironment (TME). The adenosine A2A receptor (A2AR) inhibits dendritic cell (DC) function and weakens antitumor T cell responses through hypoxia...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2458936 |
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| author | Saber Imani Parham Jabbarzadeh Kaboli Ali Babaeizad Mazaher Maghsoudloo |
| author_facet | Saber Imani Parham Jabbarzadeh Kaboli Ali Babaeizad Mazaher Maghsoudloo |
| author_sort | Saber Imani |
| collection | DOAJ |
| description | Although neo-antigen mRNA vaccines are promising for personalized cancer therapy, their effectiveness is often limited by the immunosuppressive tumor microenvironment (TME). The adenosine A2A receptor (A2AR) inhibits dendritic cell (DC) function and weakens antitumor T cell responses through hypoxia-driven mechanisms within the TME. This review explores a novel strategy combining neo-antigen mRNA vaccines with A2AR antagonists (A2ARi). By targeting A2AR, this approach reduces TME-induced immunosuppression, enhances DC activation, and improves neo-antigen presentation. The review also discusses lipid nanoparticles (LNPs) to co-deliver A2ARi and mRNA vaccines, optimizing their effectiveness. The integration of neo-antigen mRNA-LNPs with A2ARi modulation offers a promising strategy to overcome immunosuppression, stimulate DC activation, and achieve precise anti-tumor responses with minimal off-target effects. This synergy represents significant progress in cancer immunotherapy, advancing the potential for personalized neoantigen therapies. |
| format | Article |
| id | doaj-art-af1b4bc98c3a4f269fb3913ae7e52b1a |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-af1b4bc98c3a4f269fb3913ae7e52b1a2025-01-30T12:49:37ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2458936Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunitySaber Imani0Parham Jabbarzadeh Kaboli1Ali Babaeizad2Mazaher Maghsoudloo3Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, ChinaDepartment of Biochemistry, Faculty of Medicine, Medical University of Warsaw, Warsaw, PolandFaculty of Medicine, Semnan University of Medical Sciences, Semnan, IranKey Laboratory of Epigenetics and Oncology, The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan, ChinaAlthough neo-antigen mRNA vaccines are promising for personalized cancer therapy, their effectiveness is often limited by the immunosuppressive tumor microenvironment (TME). The adenosine A2A receptor (A2AR) inhibits dendritic cell (DC) function and weakens antitumor T cell responses through hypoxia-driven mechanisms within the TME. This review explores a novel strategy combining neo-antigen mRNA vaccines with A2AR antagonists (A2ARi). By targeting A2AR, this approach reduces TME-induced immunosuppression, enhances DC activation, and improves neo-antigen presentation. The review also discusses lipid nanoparticles (LNPs) to co-deliver A2ARi and mRNA vaccines, optimizing their effectiveness. The integration of neo-antigen mRNA-LNPs with A2ARi modulation offers a promising strategy to overcome immunosuppression, stimulate DC activation, and achieve precise anti-tumor responses with minimal off-target effects. This synergy represents significant progress in cancer immunotherapy, advancing the potential for personalized neoantigen therapies.https://www.tandfonline.com/doi/10.1080/21645515.2025.2458936Neo-antigen mRNA vaccinesadenosine A2ARtargeted immunotherapytumor microenvironment |
| spellingShingle | Saber Imani Parham Jabbarzadeh Kaboli Ali Babaeizad Mazaher Maghsoudloo Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity Human Vaccines & Immunotherapeutics Neo-antigen mRNA vaccines adenosine A2AR targeted immunotherapy tumor microenvironment |
| title | Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity |
| title_full | Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity |
| title_fullStr | Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity |
| title_full_unstemmed | Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity |
| title_short | Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity |
| title_sort | neoantigen mrna vaccines and a2a receptor antagonism a strategy to enhance t cell immunity |
| topic | Neo-antigen mRNA vaccines adenosine A2AR targeted immunotherapy tumor microenvironment |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2458936 |
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