Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities

Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities

Three unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities...

Full description

Saved in:

Bibliographic Details
Main Authors:	Singamsetty Radha Krishna, Mandava Venkata Naga Brahmeshwar Rao, Tirmalaraju Satyanaryana Raju, Vurimidi Himabindu, Ghanta Mahesh Reddy
Format:	Article
Language:	English
Published:	Wiley 2008-01-01
Series:	E-Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2008/308724
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Processing and Characterization of a Polypropylene Biocomposite Compounded with Maleated and Acrylated Compatibilizers
by: Brent A. Nerenz, et al.
Published: (2012-01-01)

New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities
by: Reddivari Chenna Krishna Reddy, et al.
Published: (2013-01-01)

Poly(Lactic Acid) Filled with Cassava Starch-g-Soybean Oil Maleate
by: Nopparut Kiangkitiwan, et al.
Published: (2013-01-01)

Simultaneous spectrofluorometric analysis of tablets containing hydrochlorothiazide combined with timolol maleate or amiloride hydrochloride
by: Wedian Fadel, et al.
Published: (2020-09-01)

Simultaneous Estimation of Glimepiride, Rosiglitazone and Pioglitazone Hydrochloride in the Pharmaceutical Dosage Form
by: Freddy H. Havaldar, et al.
Published: (2010-01-01)

Rosiglitazone and Pioglitazone Alter Aromatase Kinetic Properties in Human Granulosa Cells
by: Takako Araki, et al.
Published: (2011-01-01)

Efficacy of Trimebutine Maleate (Trimedat®) in the Treatment of Patients with Functional Dyspepsia: Results of the “TREND” Observational Study
by: S. S. Kardasheva, et al.
Published: (2018-11-01)

Neutron Scattering on Impurity Nanoclusters in Gel Samples
by: V. B. Efimov, et al.
Published: (2015-01-01)

Retracted: Efficacy and Mechanism of Trimebutine Maleate Combined with Lactulose in the Treatment of Constipation-Predominant Irritable Bowel Syndrome in the Elderly
by: Emergency Medicine International
Published: (2024-01-01)

Safety and Efficacy of Adding Fixed-Combination Brinzolamide/Timolol Maleate to Prostaglandin Therapy for Treatment of Ocular Hypertension or Glaucoma
by: Anton Hommer, et al.
Published: (2015-01-01)

Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway
by: Maoping Cai, et al.
Published: (2025-01-01)

Pioglitazone versus Rosiglitazone: Effects on Lipids, Lipoproteins, and Apolipoproteins in Head-to-Head Randomized Clinical Studies
by: Mark A. Deeg, et al.
Published: (2008-01-01)

Combined Rosiglitazone and Forskolin Have Neuroprotective Effects in SD Rats after Spinal Cord Injury
by: Qing-qi Meng, et al.
Published: (2018-01-01)

Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR Heterodimerization
by: Jiamiao Hu, et al.
Published: (2018-01-01)

Activation of PPAR𝛾 by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats
by: Mahmoud Mansour, et al.
Published: (2009-01-01)

Tackling impurities in CCS pipelines: An optimization-based approach
by: Mohamed Mazhar Laljee, et al.
Published: (2025-06-01)

The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects
by: Galina S. Bogatkevich, et al.
Published: (2012-01-01)

Effect of Rosiglitazone and Insulin Combination Therapy on Inflammation Parameters and Adipocytokine Levels in Patients with Type 1 DM
by: Metin Guclu, et al.
Published: (2015-01-01)

Synthesis and Bioactivity of Some New 3-Alkyl-2,4-diisopropyl-1,2,4,5-tetrahydro-benzo[e][1,3,2]-diazaphosphepine 3-sulfides/selenides
by: Ch. Mohan, et al.
Published: (2008-01-01)

Unusual Operation of the Junction Transistor Based on Dynamical Behavior of Impurities
by: Roberto Baca Arroyo
Published: (2018-01-01)

Practical Approach for the Determination of Response Factors of Impurities in Drugs by HPLC
by: Dharmendra Kushwah, et al.
Published: (2011-01-01)

Impurity, Moral Substantiality, and Social Control: A Gender Perspective
by: Alice Van den Bogaert
Published: (2025-01-01)

Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design
by: Szabó Zoltán-István, et al.
Published: (2016-06-01)

Influence of Rosiglitazone on the Expression of PPARγ, NF-κB, and TNF-α in Rat Model of Ulcerative Colitis
by: Jing-Wei Mao, et al.
Published: (2012-01-01)

Development and Validation of a LC/MS/MS Method for the Determination of Duloxetine in Human Plasma and Its Application to Pharmacokinetic Study
by: D. Chandrapal Reddy, et al.
Published: (2012-01-01)

Erratum to “Development and Validation of a LC/MS/MS Method for the Determination of Duloxetine in Human Plasma and Its Application to Pharmacokinetic Study”
by: D. Chandrapal Reddy, et al.
Published: (2013-01-01)

Rapid Discrimination of Chlorpheniramine Maleate and Assessment of Its Surface Content Uniformity in a Pharmaceutical Formulation by NIR-CI Coupled with Statistical Measurement
by: Luwei Zhou, et al.
Published: (2014-01-01)

IMPACT OF WATER IMPURITIES ON DRILLING FLUID PROPERTIES: A CASE STUDY
by: Amel Habeeb Assi
Published: (2025-02-01)

NON-METALLIC IMPURITIES AND FORMING OF THE STRUCTURE OF THE MODIFIED HIGH-MANGANESE STEEL
by: A. I. Garost
Published: (2006-02-01)

Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan Medoxomil
by: G. Venkanna, et al.
Published: (2013-01-01)

The influence of oxygen as impurity substitution defects on the electronic structure of binary graphene
by: V. V. Bolotov, et al.
Published: (2020-09-01)

Forced degradation of tacrolimus and the development of a UHPLC method for impurities determination
by: Peterka Tanja Rozman, et al.
Published: (2019-09-01)

Anomalous Behavior of the Non-Hermitian Topological System with an Asymmetric Coupling Impurity
by: Junjie Wang, et al.
Published: (2025-01-01)

Rosiglitazone, a Ligand to PPARγ, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation
by: María Sánchez-Aguilar, et al.
Published: (2019-01-01)

Expression of Concern on “The Novel Oral Drug Subetta Exerts an Antidiabetic Effect in the Diabetic Goto-Kakizaki Rat: Comparison with Rosiglitazone”
by: Journal of Diabetes Research
Published: (2019-01-01)

PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice
by: Ying Sun, et al.
Published: (2013-01-01)

A Lower Bound on the Critical Momentum of an Impurity in a Bose–Einstein Condensate
by: Hinrichs, Benjamin, et al.
Published: (2024-11-01)

Application of HPLC with ELSD Detection for the Assessment of Azelaic Acid Impurities in Liposomal Formulation
by: Stanislaw Han, et al.
Published: (2013-01-01)

Simultaneous HPLC Determination of Chlordiazepoxide and Mebeverine HCl in the Presence of Their Degradation Products and Impurities
by: Rania N. El-Shaheny, et al.
Published: (2015-01-01)

Structure Identification and Risk Assurance of Unknown Impurities in Pramipexole Oral Drug Formulation
by: Raymond R. Tjandrawinata, et al.
Published: (2024-01-01)