Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing.

Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing.

The sinoatrial node (SAN) is heterogeneous in terms of cell size, ion channels, current densities, connexins and electrical coupling. For example, Nav1.5 (responsible for INa) and Cx43 (responsible for electrical coupling) are absent from the centre of the SAN (normally the leading pacemaker site),...

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Bibliographic Details
Main Authors: Shin Inada, Henggui Zhang, James O Tellez, Nitaro Shibata, Kazuo Nakazawa, Kaichiro Kamiya, Itsuo Kodama, Kazuyuki Mitsui, Halina Dobrzynski, Mark R Boyett, Haruo Honjo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094565&type=printable
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