Leveraging CAR macrophages targeting c-Met for precision immunotherapy in pancreatic cancer: insights from single-cell multi-omics

Leveraging CAR macrophages targeting c-Met for precision immunotherapy in pancreatic cancer: insights from single-cell multi-omics

Abstract Background Pancreatic cancer is known for its poor prognosis and resistance to conventional therapies, largely due to the presence of cancer stem cells (CSCs) and aggressive angiogenesis. Effectively targeting these CSCs and associated angiogenic pathways is crucial for effective treatment....

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Bibliographic Details
Main Authors: Lingyu Hu, Xiaoguang Wang, Zhengwei Song, Fei Chen, Bin Wu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Medicine
Subjects:
Pancreatic cancer
CAR macrophages
c-Met
Single-cell multi-omics
Angiogenesis
Cancer stem cells
Online Access:https://doi.org/10.1186/s10020-024-00996-4
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