Synthesis, Anticancer Screening, and In Silico Evaluations of Thieno[2,3-<i>c</i>]pyridine Derivatives as Hsp90 Inhibitors

Synthesis, Anticancer Screening, and In Silico Evaluations of Thieno[2,3-<i>c</i>]pyridine Derivatives as Hsp90 Inhibitors

<b>Background</b>: Thieno[2,3-<i>c</i>]pyridines and their analogs are not well explored for their anticancer properties. Hence, our research aimed to establish the anticancer potential of thieno[2,3-<i>c</i>]pyridines through cell-based assays and in silico evalu...

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Main Authors: Balakumar Chandrasekaran, Mohammad F. Bayan, Ali Hmedat, Bilal A. Al-Jaidi, Deniz M. Al-Tawalbeh, Duaa Abuarqoub, Anas J. Rasras, Da’san M. M. Jaradat, Abdel Naser Dakkah, Wafa Hourani, Rajshekhar Karpoormath
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Pharmaceuticals
Subjects:
Hsp90
anticancer agents
thieno[2,3-<i>c</i>]pyridines
cell cycle analysis
molecular docking
ADME prediction
Online Access:https://www.mdpi.com/1424-8247/18/2/153
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