Pulling Forces Differentially Affect Refolding Pathways Due to Entangled Misfolded States in SARS-CoV-1 and SARS-CoV-2 Receptor Binding Domain

Pulling Forces Differentially Affect Refolding Pathways Due to Entangled Misfolded States in SARS-CoV-1 and SARS-CoV-2 Receptor Binding Domain

Single-molecule force spectroscopy (SMFS) experiments can monitor protein refolding by applying a small force of a few piconewtons (pN) and slowing down the folding process. Bell theory predicts that in the narrow force regime where refolding can occur, the folding time should increase exponentially...

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Bibliographic Details
Main Authors: Pham Dang Lan, Edward P. O’Brien, Mai Suan Li
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Biomolecules
Subjects:
protein folding
SARS-CoV-2 RBD
SARS-CoV-1 RBD
quenched force
lasso entanglement
folding pathways
Online Access:https://www.mdpi.com/2218-273X/14/10/1327
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https://www.mdpi.com/2218-273X/14/10/1327

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