Inhibiting NHEJ in HNSCC cell lines by the ligase IV inhibitor SCR130 has limited radiosensitizing effects

Inhibiting NHEJ in HNSCC cell lines by the ligase IV inhibitor SCR130 has limited radiosensitizing effects

Abstract Radiotherapy (RT) is a relevant treatment for head and neck squamous cell carcinoma (HNSCC) patients but radioresistance, which depends on DNA damage response (DDR), restrains outcome. Therefore, manipulating DDR by small molecule inhibitors (SMI) is a promising treatment option. The main D...

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Bibliographic Details
Main Authors: Laura S. Hildebrand, Tina Jost, Marion Schindler, Anja Derer, Gregor Fuhrmann, Rainer Fietkau, Luitpold V. Distel
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Ligase IV
SCR130
Head and neck squamous cell carcinoma
DNA damage response
Radiation sensitivity
Ionizing radiation
Online Access:https://doi.org/10.1038/s41598-025-03159-5
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https://doi.org/10.1038/s41598-025-03159-5

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