RORγt inverse agonists demonstrating a margin between inhibition of IL-17A and thymocyte apoptosis.

RORγt inverse agonists demonstrating a margin between inhibition of IL-17A and thymocyte apoptosis.

Multiple genetic associations suggest a causative relationship between Th17-related genes coding for proteins, such as IL-17A, IL-23 and STAT3, and psoriasis. Further support for this link comes from the findings that neutralizing antibodies directed against IL-17A, IL-17RA and IL-23 are efficacious...

Full description

Saved in:
Bibliographic Details
Main Authors: Mia Collins, Rikard Pehrson, Hanna Grindebacke, Agnes Leffler, Marie Ramnegård, Helena Rannikmäe, Nina Krutrök, Linda Yrlid, Charlotte Pollard, Ian Dainty, Frank Narjes, Stefan von Berg, Antonio Llinas, Anna Malmberg, Jane McPheat, Eva Hansson, Elisabeth Bäck, Jenny Bernström, Thomas G Hansson, David Keeling, Johan Jirholt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0317090
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1371/journal.pone.0317090

Similar Items