Pregnancy Ketonemia and Development of the Fetal Central Nervous System
Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/1242901 |
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| author | Agata Bronisz Mateusz Ozorowski Magdalena Hagner-Derengowska |
| author_facet | Agata Bronisz Mateusz Ozorowski Magdalena Hagner-Derengowska |
| author_sort | Agata Bronisz |
| collection | DOAJ |
| description | Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The data available proves a changing influence of ketones on the central nervous system during fetal life and in adults as well. Ketone bodies freely pass through the placenta. They can affect fetal growth and organ damage development, especially the central nervous system. As agreed in the current recommendation of the diabetes associations, it is not obligatory for the attending doctor to conduct a routine inspection of ketone bodies during diabetes treatment in pregnancy. This article is a literature review of ketones’ effect on the central nervous system and an attempt to initiate discussion whether we should consider including ketonemia assessment into the standard care package for pregnant women with diabetes and begin some research on the explanation of its influence on fetal development. |
| format | Article |
| id | doaj-art-ae1aafb981e7439b84bed8cbcbb3100a |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ae1aafb981e7439b84bed8cbcbb3100a2025-02-03T05:43:56ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/12429011242901Pregnancy Ketonemia and Development of the Fetal Central Nervous SystemAgata Bronisz0Mateusz Ozorowski1Magdalena Hagner-Derengowska2Endocrinology and Diabetology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 9 Skłodowskiej-Curie Street, 85-094 Bydgoszcz, PolandEndocrinology and Diabetology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 9 Skłodowskiej-Curie Street, 85-094 Bydgoszcz, PolandClinical Neuropsychology, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 9 Skłodowskiej-Curie Street, 85-094 Bydgoszcz, PolandGlucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The data available proves a changing influence of ketones on the central nervous system during fetal life and in adults as well. Ketone bodies freely pass through the placenta. They can affect fetal growth and organ damage development, especially the central nervous system. As agreed in the current recommendation of the diabetes associations, it is not obligatory for the attending doctor to conduct a routine inspection of ketone bodies during diabetes treatment in pregnancy. This article is a literature review of ketones’ effect on the central nervous system and an attempt to initiate discussion whether we should consider including ketonemia assessment into the standard care package for pregnant women with diabetes and begin some research on the explanation of its influence on fetal development.http://dx.doi.org/10.1155/2018/1242901 |
| spellingShingle | Agata Bronisz Mateusz Ozorowski Magdalena Hagner-Derengowska Pregnancy Ketonemia and Development of the Fetal Central Nervous System International Journal of Endocrinology |
| title | Pregnancy Ketonemia and Development of the Fetal Central Nervous System |
| title_full | Pregnancy Ketonemia and Development of the Fetal Central Nervous System |
| title_fullStr | Pregnancy Ketonemia and Development of the Fetal Central Nervous System |
| title_full_unstemmed | Pregnancy Ketonemia and Development of the Fetal Central Nervous System |
| title_short | Pregnancy Ketonemia and Development of the Fetal Central Nervous System |
| title_sort | pregnancy ketonemia and development of the fetal central nervous system |
| url | http://dx.doi.org/10.1155/2018/1242901 |
| work_keys_str_mv | AT agatabronisz pregnancyketonemiaanddevelopmentofthefetalcentralnervoussystem AT mateuszozorowski pregnancyketonemiaanddevelopmentofthefetalcentralnervoussystem AT magdalenahagnerderengowska pregnancyketonemiaanddevelopmentofthefetalcentralnervoussystem |