The effects of inhibiting IRE1α on the viability of ovarian granulosa cells

The effects of inhibiting IRE1α on the viability of ovarian granulosa cells

Abstract IRE1α, a type I transmembrane protein characterized by a cytoplasmic serine/threonine kinase domain, is related to ER stress and ER function maintenance. In this study, 4µ8c, a highly effective selective inhibitor of IRE1α RNase, and APY29, an ATP competitive inhibitor, inhibiting IRE1α aut...

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Main Authors: Chao Li, Yong-Peng Tan, Tie-Gang Meng, Di Gao, Ke Xu, You-Hui Lu, Li-Tao Yi, Shu-Chen Liu, Guang Wang, Qing-Yuan Sun, Xiao-Can Lei
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Ovarian granulosa cells
IRE1α
APY29
4µ8c
Chaperones
Cell apoptosis
Online Access:https://doi.org/10.1038/s41598-025-03600-9
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https://doi.org/10.1038/s41598-025-03600-9

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