The tradeoffs between persistence and mutation rates at sub-inhibitory antibiotic concentrations in Staphylococcus aureus

The tradeoffs between persistence and mutation rates at sub-inhibitory antibiotic concentrations in Staphylococcus aureus

ABSTRACT The rational design of the antibiotic treatment of bacterial infections employs these drugs to reach concentrations that exceed the minimum needed to prevent the replication of the target bacteria. However, within a treated patient, spatial and physiological heterogeneity promotes antibioti...

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Main Authors: Alysha S. Ismail, Brandon A. Berryhill, Teresa Gil-Gil, Joshua A. Manuel, Andrew P. Smith, Fernando Baquero, Bruce R. Levin
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:Microbiology Spectrum
Subjects:
antibiotics
minimum inhibitory concentration
pharmacodynamics
population biology
antibiotic resistance mutation rate
bacterial persistence
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02479-24
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https://journals.asm.org/doi/10.1128/spectrum.02479-24

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