TEC-mediated tRF-31R9J regulates histone lactylation and acetylation by HDAC1 to suppress hepatocyte ferroptosis and improve non-alcoholic steatohepatitis

TEC-mediated tRF-31R9J regulates histone lactylation and acetylation by HDAC1 to suppress hepatocyte ferroptosis and improve non-alcoholic steatohepatitis

Abstract Background Tectorigenin (TEC) is a monomer of anthocyanin, which we found exhibits hepatoprotective effects. tRNA-derived fragments (tRFs) and ferroptosis play important roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). Recent discoveries have revealed that histone lactylat...

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Bibliographic Details
Main Authors: Juanjuan Zhu, Xian Wu, Mao Mu, Quan Zhang, Xueke Zhao
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Clinical Epigenetics
Subjects:
Tectorigenin
Histone lactylation
Ferroptosis
tRF-31-R9JP9P9NH5HYD
Non-alcoholic steatohepatitis
Online Access:https://doi.org/10.1186/s13148-025-01813-3
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https://doi.org/10.1186/s13148-025-01813-3

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